• Van-Thoai Nguyen Hung Yen University of Technology and Education
  • Ching-Yin Kang National Kaohsiung University of Science and Technology, Kaohsiung 807, Taiwan
Keywords: Titanium Alloy, Anodic Oxidation, Simulated Body Fluid, Hydroxyapatite


This study presents a method for synthesizing hydroxyapatite (HA) on the Ti-6Al-4V substrate by using a solution containing calciumd acetate (CA), calcium glycerophosphate hydrate (Ca-GP), and different concentrations of H2SO4 as the electrolyte for anodic treatment. The results found that the anodic method is suitable for Ti-6Al-4V titanium alloy to form an oxide film containing Ca and P that will promote HA growth. Moreover, these anodic oxide films display a highly porous structure on the sample surface. This reduces the induction time of the HA crystals and the time required for the surface to be completely covered by HA after the samples are immersed in simulated body fluids (SBF). Besides, at a higher concentration of H2SO4 , the anodic oxide films containing more Ca that will increase the apatite nuclei and promote the growth of HA was easily obtained in the electrolyte with CA, Ca-GP.


Jang, J. H., Oh, B., & Lee, E. J., Crystalline hydroxyapatite/graphene oxide complex by lowtemperature sol-gel synthesis and its characterization. Ceramics International, 2021, 47(19), pp. 27677-27684.

Lei, Y., Xu, Z., Ke, Q., Yin, W., Chen, Y., Zhang, C., & Guo, Y., Strontium hydroxyapatite/chitosan nanohybrid scaffolds with enhanced osteoinductivity for bone tissue engineering. Materials Science and Engineering: C, 2017, 72, pp. 134-142.

Jyoti, J., et al., Improved nanomechanical and in-vitro biocompatibility of graphene oxide-carbon nanotube hydroxyapatite hybrid composites by synergistic effect. Journal of the Mechanical Behavior of Biomedical Materials, 2021, 117, 104376.

Niinomi, M., Liu, Y., Nakai, M., Liu, H., & Li, H., Biomedical titanium alloys with Young’s moduli close to that of cortical bone. Regenerative biomaterials, 2016, 3(3), pp. 173-185.

Hall, D. J., et al., Nanoscale surface modification by anodic oxidation increased bone ingrowth and reduced fibrous tissue in the porous coating of titanium–alloy femoral hip arthroplasty implants. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2017, 105(2), pp. 283-290.

Kokubo, T., & Takadama, H., How useful is SBF in predicting in vivo bone bioactivity?. Biomaterials, 2006, 27(15), pp. 2907-2915.

Chen, X., & Mao, S. S., Synthesis of titanium dioxide (TiO2) nanomaterials. Journal of nanoscience and nanotechnology, 2006, 6(4), pp. 906-925.

Lu, H. B., Campbell, C. T., Graham, D. J., & Ratner, B. D., Surface Characterization Of Hydroxyapatite And Related Calcium Phosphates By Xps And Tof-Sims. Analytical Chemistry, 2000, 72(13), pp. 2886-2894.

How to Cite
Van-Thoai Nguyen, & Ching-Yin Kang. (2022). FORMATION AND CHARACTERISTICS OF HYDROXYAPATITE FILM GROWN ON TITANIUM ALLOY Ti-6Al-4V SUBSTRATES BY ANODIC TREATMENT. UTEHY Journal of Science and Technology, 33, 98-102. Retrieved from